NC DEPARTMENT OF
HEALTH AND
HUMAN SERVICES
ROY COOPER • Governor
MANDY COHEN, MD, MPH • Secretary
DANNY STALEY • Director, Division of Public Health
Developed by the North Carolina Division of Public Health, Communicable Disease Branch
Lyme Disease Surveillance Summary from 2012—2017
Background
Lyme disease is a bacterial infection caused by Borrelia burgdorferi, and is transmitted to humans and animals
through the bite of infected Ixodes scapularis (blacklegged) ticks. Symptoms of Lyme disease include fever,
headache, fatigue, and a characteristic bull's-eye rash called erythema migrans (EM). If left untreated, infection can
spread to the joints, heart, and nervous system. Diagnosis is based on the presence of symptoms, clinical findings
(like an EM rash), exposure to ticks, and serological testing. Most cases of Lyme disease are effectively treated with
antibiotics. The best way to mitigate Lyme disease is prevention.
Symptomology
Early signs of Lyme disease include fever, chills, headache, fatigue, muscle and joint aches, swollen lymph nodes, and
EM rash. It is important to note that an EM rash only occurs in 70-80% of patients, and can take up to 30 days to
appear. Untreated Lyme disease can cause a variety of symptoms including severe headaches and neck stiffness,
additional EM rashes, arthritis with severe joint pain and swelling, particularly in the knees and other large joints,
facial palsy and heart conditions associated with Lyme carditis.
Epidemiology
National
Lyme disease cases are centered in the Northeast and upper Midwest of the United States, with 96% of cases
reported from 14 states: Connecticut, Delaware, Maine, Maryland, Massachusetts, Minnesota, New Hampshire, New
Jersey, New York, Pennsylvania, Rhode Island, Vermont, Virginia and Wisconsin. The average incidence rate of Lyme
disease between 2013-2016 was 8.1 cases per 100,000 residents, with incidence rates of the highest states reaching
>50 cases per 100,000.
North Carolina
In the state of North Carolina, the number of confirmed and probable cases of Lyme disease has increased over the
past five years. The highest incidence of Lyme disease in 2017 is clustered to the northwestern portion of the state,
particularly in Ashe, Alleghany, Surry, Watauga, Wilkes, and Madison counties. The 5-year average incidence rate
of Lyme disease in North Carolina between 2012-2016 was 1.97 confirmed and probable cases per 100,000
residents.
Diagnosis
Lyme disease can be physician diagnosed based on the symptoms outlined above, a history of tick exposure and
serological testing. Serological blood tests are effective when used correctly and performed with validated methods.
Lab tests are not recommended for patients who do not have symptoms of typical Lyme disease to avoid both
misdiagnosis and the treatment of Lyme disease when the true cause if illness is something else.
Prevention
Reducing exposure to ticks is the best defense against Lyme disease. There are a number of methods that can be
used to prevent tickborne illness:
• Wear permethrin treated clothing (0.5%) when exploring the outdoors.
• Use Environmental Protection Agency (EPA) registered insect repellents containing DEET or picaridin to
deter ticks.
• Avoid ticks in wooded/brushy areas with high grasses and leaf litter by walking in the center of trails.
• Check clothing for ticks you may have encountered while outdoors; shower soon after returning indoors.