Penile Cancer
A Fact Sheet from the North Carolina Central Cancer Registry, State Center for Health Statistics
An HPV-associated cancer is a specific cellular type of
cancer that is diagnosed in a part of the body where HPV
(Human Papilloma Virus) is often found. These parts of
the body include the cervix, vagina, vulva, penis, anus,
rectum, and oropharynx (back of the throat, including the
base of the tongue and tonsils). According to the CDC,
each year there are about 34,800 new cancer cases caused
by HPV in the United States.
About 60% of penile cancers are caused by HPV. It
is estimated that 54 males in North Carolina will be
diagnosed with Penile cancer and 1 1 males will die of
cancer of the Penis in 2020.
Figure 1. 2013-2017 Percent of Penile Cancer
Cases by Age Group
Percentages may net add up to 100 percent due to roundng.
Incidence
The percentage of cases of Penile cancer from 2013 to
2017 is displayed by age group in Figure 1. About 5.6
percent of Penile cancer cases were diagnosed in people
younger than 45.
October 2020
From 2013 to 2017, the age-adjusted incidence rate for
Penile cancer in North Carolina was 0.9 per 100,000
people per year. Non-Hispanic Black males have the
highest incidence rate for Penile cancer (Figure 2).
From 2003 to 2017, Penile cancer incidence rates have
been stable for white and minority males (Figure 3).
Figure 2. 2013-2017 Penile Cancer
Incidence Rates by Race and Ethnicity
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All Races and Non-Hispanic Non-Hispanic Hispanics
Ethnicities Whites Blacks
Race and Ethnicity
■ Males
Rate per 100,000 Population
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3. 2003-2017
Penile Cancer
Incidence Trends by Race
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NC DEPARTMENT OF
HEALTH AND
HUMAN SERVICES
Division of Public Health
State of North Carolina ♦ www.nc.gov ♦ Department of Health and Human Services
www.ncdhhs.gov ♦ North Carolina Division of Public Health ♦ www.publichealth.nc.gov
State Center for Health Statistics ♦ www.schs.state.nc.us
North Carolina DHHS is an equal opportunity employer and provider.
Stage at Diagnosis*
Figure 4 shows the stage distribution of Penile cancer
cases diagnosed from 2013 to 2017. Approximately 90.9
percent of Penile cancer cases were diagnosed at the
localized or regional stage.
Figure 4. 2013-2017 Percent of Penile Cancer
Cases by Stage
Unknown
7.8%
Di slant
1.3%
Regional
30.6%
Percentages may not add up to 100 percent due to rounding.
Figure 5. 2013-2017 Percent of Penile
Cancer Deaths by Age Group
20-44, 9.3%
85+ , 14.0%
65-84, 55.8%
45-64, 20.9%
Percentages may not add up to 100 percent due to founding.
The age-adjusted mortality rate of Penile cancer from
2013 to 2017 was 0.2 per 100,000 people per year.
When comparing Penile cancer rates by race and ethnicity,
non-Hispanic Black males have the highest mortality
rate (Figure 6).
Figure 6. 2013-2017 Penile Cancer Mortality
Rates by Race and Ethnicity
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All Races and Non-Hispanic
Ethnicities Whites
Non-Hispanic
Blacks
Hispanics
Mortality
From 2013 to 2017, the percentage of Penile cancer
deaths is displayed by age group in Figure 5. About 55.
percent of deaths occurred in people ages 65 to 84.
i Males
From 2003 to 2017, Penile cancer mortality rates have
increased for minority males and been stable for white
males (Figure 7).
Figure 7. 2003-2017 Penile Cancer
Mortality Trends by Race
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Data Sources and Methods
Data on North Carolina cases were obtained from the North Carolina Central Cancer Registry (CCR). Hospitals are the primary
source of data. The CCR supplements hospital data with reports from physicians who diagnose cases in a non-hospital setting. The
CCR also collects data from pathology laboratories and freestanding treatment centers. Data on cancer deaths were obtained from
Statistical Services in the State Center for Health Statistics. Population data from the National Center for Health Statistics were
used in the denominators of the rates, which are expressed per 100,000 people. Rates were age-adjusted using the 2000 United
States Census data. To examine trends, three- year overlapping rates were used to improve stability over time. Stage at diagnosis
was defined according to Surveillance, Epidemiology, and End Results Summary Stage guidelines as in situ, localized, regional,
distant, and unknown/NA. For further information about the North Carolina CCR, visit www.schs.state.nc.us/units/ccr/.
* According to the National Cancer Institute (NCI), “many cancer registries, such as NCI’s Surveillance, Epidemiology, and End Results Program (SEER), use summary
staging. This system is used for all types of cancer. It groups cancer cases into five main categories: In situ Abnormal cells arc present only in the layer of cells in
which they developed. Localized -Cancer is limited to the organ in which it began, without evidence of spread. Regional Cancer has spread beyond the primary
site to nearby lymph nodes or organs and tissues. Distant — Cancer has spread from die primary site to distant organs or distant lymph nodes. Unknown —There is not
enough information to determine die stage." Additional information on staging can be found at https://www.canccr.gov/about-canccr/diagnosis-staging/staging.